Septerna Inc (SEPN)

Currency in USD
43.93
+0.13(+0.30%)
Closed·
43.11-0.82(-1.86%)
·
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Fair Value
Day's Range
43.4944.93
52 wk Range
10.7451.10
Key Statistics
Prev. Close
43.8
Open
44.65
Day's Range
43.49-44.93
52 wk Range
10.74-51.1
Volume
383.37K
Average Volume (3m)
437.02K
1-Year Change
301.9213%
Book Value / Share
8.58
Fair Value
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Fair Value Upside
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SEPN Scorecardpro icon
Company’s Health
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Fair Value
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Fair Price
Upside
Price Target
53.11
Upside
+20.90%
Members' Sentiments
Bearish
Bullish
ProTips
Analysts anticipate sales growth in the current year

Septerna Inc News & Analysis

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Technical Analysis

Summary
Strong Sell
Sell
Neutral
Buy
Strong Buy
Neutral
Technical Indicators
Strong Sell
Moving Averages
Buy

Analyst Ratings

10 Buy
0 Hold
0 Sell
Ratings:
10 analysts
Overall Consensus
Strong Buy

Analysts 12-Month Price Target:

Average 53.11
(+20.90% Upside)
Firm
ArticlePositionPrice TargetUpside / DownsideFrom Price TargetActionDate
JPMorgan
Buy48.00+9.26%38.00Maintain19-08-2026
Truist Securities
Buy59.00+34.30%43.00Maintain13-08-2026
H.C. Wainwright
Buy60.00+36.58%40.00Maintain12-08-2026
Wells Fargo
Buy50.00+13.82%48.00Maintain12-08-2026
Stifel
Buy49.00+11.54%43.00Maintain11-08-2026

Earnings

Latest Release
10-08-2026
EPS / Forecast
-0.29 / -0.74
Revenue / Forecast
26.75M / --
EPS Revisions
Last 90 days

SEPN Income Statement

Compare SEPN to Peers and Sector

Metrics to compare
SEPN
Peers
Sector
Relationship
P/E Ratio
−84.7x−7.6x−0.3x
PEG Ratio
−1.04−0.050.00
Price/Book
5.3x2.3x2.6x
Price / LTM Sales
20.8x9.7x3.1x
Upside (Analyst Target)
14.2%45.7%50.4%
Fair Value Upside
Unlock−7.4%6.4%Unlock

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves’ disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women’s health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

Ownership

Ownership Overview

Type
Common Stock Held% of Shares OutstandingMarket Value
Mutual Funds & ETFs
7.48M16.60%330.64M
Other Institutional Investors
58.12M83.40%2.57B
Public Companies & Retail Investors
0.000.00%0.00
Total
65.6M100.00%2.9B

Top Holders

Holder
% of holding
Shares Held
Date Reported
Value (In 1,000s)
Third Rock Ventures, LLC23.13%1,04,27,2504,60,884
RA Capital Management, L.P.15.52%69,95,8583,09,217

FAQ

What Is the Septerna (SEPN) Share Price Today?

The Septerna share price today is 43.93.

What is the current Septerna (SEPN) share price and day range?

As of 19-08-2026, the Septerna share price is 43.93, with a previous close of 43.80. The share price has ranged from 43.49 to 44.93 today, while the 52-week range spans from 10.74 to 51.10.

What Is the Septerna Market Cap?

As of today, Septerna market cap is 2.05B.

What Is the Septerna (SEPN) Share Price Target?

The average 12-month share price target for Septerna is 53.11, with a high estimate of 62 and a low estimate of 38. 10 analysts recommend buying, while 0 suggest selling, with an overall rating of Strong Buy and +20.90% Upside potential.

What Is Septerna's Earnings Per Share (TTM)?

The Septerna EPS (TTM) is -0.54.

When Is the Next Septerna Earnings Date?

Septerna will release its next earnings report on 10-08-2026.

From a Technical Analysis Perspective, Is SEPN a Buy or Sell?

Based on moving averages and other technical indicators, the daily buy/sell signal is Strong Buy.

What Stock Exchange Does Septerna Trade On?

Septerna is listed and trades on the Nasdaq Stock Exchange.

What Is the Stock Symbol for Septerna?

The stock symbol for Septerna is "SEPN."

How Many Times Has Septerna Stock Split?

Septerna has split 0 times.

How Many Employees Does Septerna Have?

Septerna has 123 employees.

What Is the SEPN Premarket Price?

SEPN's last pre-market stock price is 44.65. The pre-market share volume is 2,430.00, and the stock has changed by 0.85, or 1.94%.

What Is the SEPN After Hours Price?

SEPN's last after hours stock price is 43.11, the stock has changed by -0.82, or -1.86%.
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