* UK says Brexit talks are over unless EU changes course
* J D Wetherspoon slips on annual loss, job cuts
* Jupiter Fund tumbles on higher quarterly net outflows
* FTSE 100 up 1.5%, FTSE 250 falls 0.1% (Updates to close, adds comments)
By Devik Jain
Oct 16 (Reuters) - The FTSE 100 snapped a four-day losing streak on Friday after an upbeat coronavirus vaccine update from Pfizer and signs Brexit talks might continue until the year end for a possible trade deal with the European Union.
Drugmaker Pfizer Inc (NYSE: PFE ) PFE.N said it could file for U.S. authorisation of the COVID-19 vaccine it is developing with German partner BioNTech 22UAy.F as early as late November. blue-chip index .FTSE closed up 1.5%, led by pharmaceutical .FTNMX4570 , aero .FTNMX2710 , bank .FTNMX8350 and insurance .FTNMX8570 stocks.
However, the FTSE 100 and the mid-cap index logged their first weekly declines in three weeks on concerns that the new tiered coronavirus restrictions across parts of England would derail a nascent economic recovery.
"With more than half of the country under 'high' restrictions, it's hard not to discount the possibility of even tighter restrictions over the winter months," wrote Deutsche Bank (DE: DBKGn ) economist Sanjay Raja in a note.
"Despite the relatively modest increase in restrictions nationally, constraints on activity will almost certainly derail the UK's economic recovery."
Prime Minister Boris Johnson asked businesses to prepare for a no-trade deal Brexit unless the EU fundamentally changed course. mid-cap FTSE 250 index .FTMC ended 0.1% lower as J D Wetherspoon Plc JDW.L tumbled 19.4% after the pub operator posted an annual loss and announced job cuts as it called for "sensible" government measures to contain the health crisis. Fund Management Plc JUP.L shed 3.3% after the asset manager suffered one billion pounds in net outflows in the third quarter. of oil major BP Plc BP.L rose 1.4% after falling to their lowest level since 1995 in the previous session.
Luxury goods maker Burberry Group Plc BRBY.L jumped 3.2% after the world's biggest luxury goods group, LVMH LVMH.PA , said recovering sales of Louis Vuitton handbags had helped it contain the fallout from the pandemic in the third quarter.
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