* STOXX 600 down 1 pct, DAX down 0.6 pct
* Caterpillar (NYSE:CAT) profit warning dents markets
* China data disappoints
* Investors brace for Brexit vote, trade talks, FOMC
(Updates prices, adds details, quotes)
By Julien Ponthus and Helen Reid
LONDON, Jan 28 (Reuters) - European shares slid on Monday as optimism about the end of a U.S. government shutdown faded and growth worries reared their head again.
The pan-European STOXX 600 lost 0.97 percent, its biggest fall since Jan. 3, as a profit warning from Caterpillar cemented investors' pessimistic mood after data showed the second consecutive drop in Chinese industrial profits in December.
The double whammy of negative industrial news drove investors to dump risky assets, with banks, tech, autos and oil among the worst-performing.
Investors have remained highly sceptical of European stocks despite a relatively robust rally year-to-date.
"Medium-term threats to European unity, the European economy's still-anaemic growth and its dependence on trade do make us cautious toward European risk assets," said Blackrock (NYSE:BLK) global chief investment strategist Richard Turnill in a note.
A profit warning from Caterpillar CAT.N , the U.S. heavy machinery and vehicle maker seen as a bellwether for global economic activity, drove European stocks further down and abruptly ended an early rally in mining shares .SXPP . heavy machinery maker CNH Industrial CNHI.MI tumbled 3.8 percent, the biggest faller on the FTSE MIB.
Reflecting investors' fears about global growth, financials were the biggest drag on the STOXX 600, with HSBC HSBA.L , Santander SAN.MC , Allianz ALVG.DE , and BNP Paribas BNPP.PA down 0.8 to 1.8 percent.
Oil majors BP BP.L , Royal Dutch Shell RDSa.L , and Total TOTF.PA tumbled as Brent crude futures suffered their biggest one-day drop in a month on evidence of yet more growth in U.S. crude supply. oil sector .SXEP fell 1.9 percent, its biggest loss in five weeks.
In single-stock moves, German biotech firm MorphoSys MORG.DE led losers with a 7.7 percent fall after a U.S. court ruled three Morphosys patents invalid, in a lawsuit against Janssen Biotech and Genmab GEN.CO . management commented that it is disappointed and will consider all of its options (including a potential appeal)," wrote Deutsche Bank (DE:DBKGn) analysts, cutting their target price on the stock to 125 euros from 130.
Genmab shares were up 2.5 percent.
Another big loser was Alstom ALSO.PA , which fell 3.6 percent after the French group and Germany's Siemens (NS:SIEM) offered new concessions to try to satisfy the European Commission's antitrust concerns over their plan to merge.
Despite the last-minute concessions, their efforts to create a European rail champion could yet be scuppered. in Norwegian aluminium producer Norsk Hydro NHY.OL dropped 4.3 percent as aluminium prices fell following the United States' decision to lift sanctions on the world's second largest aluminium producer United Company Rusal 0486.HK . engineering consulting firm Altran Technologies ALTT.PA lost 3.1 percent after it announced it had been the target of a cyber attack that hit operations in some European countries.