TOKYO, April 17 (Reuters) - Japan's Nikkei ended little changed on Tuesday as investors turned cautious ahead of a meeting between Prime Minister Shinzo Abe and U.S. President Donald Trump which Tokyo fears may link vital security matters with touchy trade issues. Nikkei share average .N225 ended up 0.1 percent at 21,847.59 after trading in negative territory for most of the session. The broader Topix .TOPX fell 0.4 percent to 1,729.98, with 27 of its 33 sub-sectors falling.
Financial stocks underperformed, with Mitsubishi UFJ Financial Group 8306.T falling 1.0 percent and Sumitomo Mitsui Financial Group 8316.T shedding 1.3 percent. Nomura Holdings 8604.T lost 0.9 percent while MS&AD Insurance 8725.T declined 1.5 percent.
Takeda Pharmaceutical Co 4502.T soared 2.0 percent after Shire SHP.L , which faces a potential bid from Takeda, said it would sell its oncology business to unlisted French drugmaker Servier for $2.4 billion.
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