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Stifel maintains stock target, buy rating on ALNY amid HELIOS-B results

EditorNatashya Angelica
Published 03-09-2024, 06:08 pm
ALNY
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On Tuesday, Stifel, a financial services firm, maintained its Buy rating and $295.00 price target for shares of Alnylam Pharmaceuticals (NASDAQ:ALNY). The firm's stance comes after reviewing the full HELIOS-B trial data for Vutrisiran, Alnylam's drug for treating transthyretin-mediated amyloidosis (ATTR).

While the data did not provide the strong evidence anticipated to confirm Vutrisiran as the leading treatment in the market, the trial was still deemed significantly positive.

The HELIOS-B trial results were a topic of discussion among key opinion leaders (KOLs) in the medical field. One physician expects Vutrisiran to secure the majority share in first-line (1L) treatment for ATTR, while another, adopting a more measured view based on the data, predicts the drug will achieve meaningful use in both 1L and second-line (2L) treatments. These insights focus on the clinical data, which is only one aspect of the drug's potential market success.

The financial analysts also highlighted the economic advantages Vutrisiran may have as a Part-B medicine, which could further drive its uptake in the first-line treatment market. Despite the drug not emerging as the unequivocal first-line treatment at the European Society of Cardiology (ESC) congress, the analysts believe this is not necessary to achieve blockbuster status, with projected peak sales for Alnylam potentially reaching $5-$6 billion or more.

In summary, the full data from the HELIOS-B trial suggest that Vutrisiran may not have met the highest expectations but still holds a strong position in the treatment landscape for ATTR. Alnylam's stock retains a promising outlook with substantial market opportunities ahead, as reflected in Stifel's reiterated Buy rating and price target.

In other recent news, the company's second-quarter earnings report exceeded expectations in revenue and profit, primarily due to the growth of its TTR franchise and a milestone payment from a licensing agreement with Regeneron (NASDAQ:REGN). Alnylam updated its 2024 revenue guidance, now expecting product revenues to reach between $1.575 billion and $1.65 billion.

Wolfe Research maintained its Peerperform rating for Alnylam, anticipating potential regulatory approval of its drug acoramidis in November 2024. Meanwhile, TD Cowen, H.C. Wainwright, BMO Capital, and Barclays (LON:BARC) maintained their positive outlooks on Alnylam, emphasizing the potential of the company's Amvuttra treatment.

Citi also maintained a Neutral rating on Alnylam, focusing on the company's upcoming events, including the sharing of additional data at the Heart Failure Society of America meeting and the company's TTR investor day. Alnylam is preparing for potential regulatory approval, with plans to submit a supplemental New Drug Application by the end of 2024. These recent developments indicate Alnylam's commitment to advancing its product pipeline.

InvestingPro Insights

As Alnylam Pharmaceuticals (NASDAQ:ALNY) continues to navigate the competitive landscape of ATTR treatments with its drug Vutrisiran, insights from InvestingPro provide a deeper financial perspective. Alnylam's gross profit margin impresses at 87.0% for the last twelve months as of Q2 2024, indicating a strong ability to control costs relative to revenue.

Moreover, the company's liquid assets surpass short-term obligations, suggesting financial resilience in the near term. However, it is important to note that analysts do not expect Alnylam to be profitable this year, with a negative P/E ratio of -447.12 reflecting this sentiment.

In the context of market performance, Alnylam has experienced a significant three-month price total return of 74.6%, and a six-month return of 72.13%, highlighting investor confidence in the company's growth potential. This is further supported by the fact that 10 analysts have revised their earnings upwards for the upcoming period, as noted in InvestingPro Tips. For investors seeking more in-depth analysis, there are additional InvestingPro Tips available, offering a comprehensive view of Alnylam's financial health and market prospects.

With a market capitalization of $33.72 billion and a fair value estimation by analysts at $295, compared to InvestingPro's fair value estimate of $221.65, the market's valuation of Alnylam requires careful consideration. Although the company does not pay a dividend, the potential for capital appreciation, as indicated by recent price movements and analyst revisions, may be of interest to growth-focused investors.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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