Alnylam Pharmaceuticals, Inc. discovers, develops, and commercializes therapeutics based on ribonucleic acid interference. It offers ONPATTRO and AMVUTTRA for hereditary transthyretin-mediated amyloidosis; GIVLAARI for acute hepatic porphyria; OXLUMO for primary hyperoxaluria type 1; and Leqvio for hypercholesterolemia. It also develops vutrisiran, which is in phase III clinical trial for transthyretin amyloidosis (ATTR) with cardiomyopathy; Nucresiran that is in phase I clinical trial for ATTR amyloidosis; Fitusiran, which is in phase III clinical trial for hemophilia; cemdisiran that is in phase III clinical trial for Myasthenia Gravis and paroxysmal nocturnal hemoglobinuria, and geographic atrophy; and ALN-6400, which is in phase I clinical trial for bleeding disorders. In addition, the company is also developing Zilebesiran, which is in phase II clinical trial for hypertension; Rapirosiran that is in phase II clinical trial for Metabolic dysfunction-associated steatohepatitis; ALN-4324, which is in phase I clinical trial for type 2 diabetes mellitus; ALN-PNP that is in phase I clinical trial for non-alcoholic fatty liver disease; ALN-APOC3, which is in phase I clinical trial for dyslipidemia; Mivelsiran that is in phase II clinical trial for cerebral amyloid angiopathy, and phase I clinical trial for Alzheimer’s disease; and ALN-HTT02 that is in phase I clinical trial for Huntington’s disease. Further, it develops ALN-SOD, which is in phase II clinical trial for SOD1 Amyotrophic lateral sclerosis; Elebsiran that is in phase II clinical trial for Hepatitis B and D virus infections; ALN-BCAT that is in phase I clinical trial for hepatocellular carcinoma; and ALN-ANG3. It has collaborations with Regeneron Pharmaceuticals, Inc.; Roche Holding AG; Regeneron Pharmaceuticals, Inc.; Sanofi S.A.; Novartis AG; PeptiDream, Inc; Dicerna Pharmaceuticals, Inc.; and Ionis Pharmaceuticals, Inc. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts.
RNAi Pionee | Alnylam leads in RNA interference therapeutics, with a robust portfolio of approved drugs and a promising pipeline targeting rare diseases |
ATTR-CM Opportunity | Explore Alnylam's potential in the expanding ATTR-CM market, with Amvuttra poised to capture significant share in a multi-billion dollar arena |
Financial Trajectory | Analysts project profitability in 2025, with EPS estimates of $0.76. Price targets range from $250 to $500, averaging around $320 |
Competitive Edge | Delve into Amvuttra's differentiated label and Alnylam's strategic positioning against established players in the evolving ATTR-CM treatment landscape |
Metrics to compare | ALNY | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipALNYPeersSector | |
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P/E Ratio | −155.0x | −3.6x | −0.5x | |
PEG Ratio | −7.47 | −0.08 | 0.00 | |
Price/Book | 362.1x | 1.7x | 2.6x | |
Price / LTM Sales | 17.8x | 4.5x | 3.2x | |
Upside (Analyst Target) | 6.7% | 66.4% | 44.3% | |
Fair Value Upside | Unlock | −4.5% | 6.6% | Unlock |